Spiro-cyclic .beta.-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-.alpha. converting enzyme (TACE)

   
   

The present application describes novel spiro-cyclic .beta.-amino acid derivatives of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-13 membered carbocycle or heterocycle, ring C forms a 3-11 membered spiro-carbocycle or spiro-heterocycleon ring B, and the other variables are defined in the present specification, which are useful as as matrix metalloproteinases (MMP), TNF-.alpha. converting enzyme (TACE), and/or aggrecanase inhibitors.

El actual uso describe derivados ácidos beta.-amino spiro-ci'clicos de la novela del fórmula I: ## del ## STR1 o la sal aceptable forma farmacéutico de eso, en donde el anillo B es un 3-13 membered el carbocycle o el heterocycle, el anillo C forma un 3-11 membered el anillo B del spiro-carbocycle o del spiro-heterocycleon, y las otras variables se definen en la actual especificación, que son útiles como como los metalloproteinases de la matriz (MMP), la enzima que convierte de TNF-.alpha. (TACE), e inhibidores del aggrecanase.

 
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