A fluid matrix comprising cross-linked remodelable collagen from a donor
vertebrate animal is useful for regenerating hydrodynamic function in
damaged intervertebral discs in vivo. The matrix may be injectable and may
comprise cells and a plurality of purified cell growth factors. The matrix
promotes cell growth and elaboration of proteoglycans to facilitate
regeneration of native tissues. The collagen in the matrix may be
cross-linked using photooxidative catalysis and visible light, and
purified cell growth factors are preferably at least partly bone-derived.
