A method of treatment of a host with a cellular proliferative disease,
comprising contacting the host with a cephalotaxine and an
antiproliferative agent, each in an amount sufficient to modulate said
cellular proliferative disease, is described. In some embodiments, the
cephalotaxine comprises homoharringtonine (cephalotaxine,
4-methyl-2-hydroxy-2-(4-hydroxy-4-methyl pentyl) butanediocate ester).
Antiproliferative agents of the invention comprise alkylating agents,
intercalating agents, metal coordination complexes, pyrimidine
nucleosides, purine nucleosides, inhibitors of nucleic acid associated
enzymes and proteins, and agents affecting structural proteins and
cytoplasmic enzymes.
