IAPs associated cell cycle proteins, compositions and methods of use

   
   

The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

A invenção atual é dirigida aos polypeptides da novela, aos ácidos nucleic e às moléculas relacionadas que têm um efeito sobre ou relacionada ao ciclo da pilha. São fornecidos também nisto os vetores e as pilhas de anfitrião que compreendem aquelas seqüências do ácido nucleic, moléculas chimeric do polypeptide que compreendem os polypeptides da invenção atual fundida às seqüências heterologous do polypeptide, os antibodies que ligam aos polypeptides da invenção atual e aos métodos para produzir os polypeptides da invenção atual. São fornecidos mais mais pela invenção atual os métodos para identificar as composições da novela que bioactivity intermediário do ciclo da pilha, e o uso de tais composições no diagnóstico e tratamento da doença.

 
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