Induction of programmed cell death by N5 gene

   
   

The present invention concerns methods and compositions for treating cancer in a subject. These methods and compositions utilize the activities associated with the N5 gene product, p84N5. p84N5 contains a functional death domain, can interact with the retinoblastoma gene product and is normally localized to the nucleus of cells. Increasing the activity level of p84N5 in cancer cells is beneficial for the treatment of cancer.

La actual invención se refiere a métodos y a las composiciones para tratar el cáncer en un tema. Estos métodos y composiciones utilizan las actividades asociadas al producto del gene N5, p84N5. p84N5 contiene un dominio funcional de la muerte, puede obrar recíprocamente con el producto del gene del retinoblastoma y se localiza normalmente al núcleo de células. El aumento del nivel de actividad de p84N5 en células de cáncer es beneficioso para el tratamiento del cáncer.

 
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