Ophthalmic, otic and nasal compositions containing a new class of
antibiotics (e.g., moxifloxacin) are disclosed. The compositions
preferably also contain one or more anti-inflammatory agents. The
compositions may be utilized to treat ophthalmic, otic and nasal
conditions by topically applying the compositions to the affected tissues.
The compositions and methods of the invention are particularly useful in
the treatment of acute otitis externa infections and ophthalmic infections
attributable to one or both of two newly identified Microbacterium
species, Microbacterium otitidis and Microbacterium alconae.