Novel anti-estrogenic compounds are provided which are useful to treat a
variety of disorders, particularly estrogen-dependent disorders. Preferred
compounds have a 1,3,5-estratriene nucleus, and are substituted at the
C-17 or C-11 position with a molecular moiety which renders the compounds
effective to competitively block the binding of estrogen to its receptor.
Particularly preferred compounds are 17-desoxy-1,3,5-estratrienes.
Therapeutic methods and pharmaceutical compositions are provided as well.
