Use of a cytokine-producing lactococcus strain to treat colitis

   
   

An administration strategy for the delivery at the intestinal mucosa of cytokines or cytokine antagonists, preferably of acid sensitive anti-inflammatory agents, for example, IL10 and/or soluble TNF receptor via the oral route. Preferably, inoculation occurs along with a suspension of recombinant Lactococcus lactis cells, which had been engineered to produce the respective proteins.

Een beleidsstrategie voor de levering bij intestinale mucosa van cytokines of cytokineantagonisten, bij voorkeur van zure gevoelige anti-inflammatory agenten, bijvoorbeeld, IL10 en/of oplosbare receptor TNF via de mondelinge route. Bij voorkeur, komt de inenting samen met een opschorting van recombinante lactis Lactococcus cellen voor, die waren gebouwd om de respectieve proteïnen te produceren.

 
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