Stabilized pharmaceutical composition

   
   

The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula ##STR1## wherein R.sup.1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R.sup.2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R.sup.3 and R.sup.5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R.sup.4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt stabilizing agent, is physically stable. Magnesium and calcium basic inorganic salt stabilizing agents are particularly useful.

Фармацевтическим составом вымысла, который состоит из смеси бензимидазола ## ## STR1 формулы при котором R.sup.1 водоподом, алкилом, галоидом, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, окси, алкоксидная, hydroxyalkyl, trifluoromethyl, ацил, carbamoyloxy, нитро, acyloxy, арил, aryloxy, alkylthio или alkylsulfinyl, R.sup.2 будет водопод, алкил, ацил, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl или alkylsulfonyl, R.sup.3 и R.sup.5 этим же или друг и кажд водопод, алкил, алкоксидный или alkoxyalkoxy, R.sup.4 водоподом, алкилом, алкоксидными который могут опционно быть fluorinated, или alkoxyalkoxy, и м будет интежер 0 через 4, и вещество основного неорганического соли стабилизируя, физическ стабилизировано. Вещества основного неорганического соли магния и кальция стабилизируя определенно полезны.

 
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