A novel calcium receptor active compound having the formula is provided:
Ar.sub.1 --[CR.sup.1 R.sup.2 ].sub.p --X--[CR.sup.3 R.sup.4 ].sub.q
--[CR.sup.5 R.sup.6 ]--NR.sup.7 --[CR.sup.8 R.sup.9 ]--Ar.sub.2
wherein:
Ar.sub.1 is selected from the group consisting of aryl, heteroaryl,
bis(arylmethyl)amino, bis(heteroarylmethyl)amino and
arylmethyl(heteroarylmethyl)amino;
X is selected from the group consisting of oxygen, sulfur, sulfinyl,
sulfonyl, carbonyl and amino;
R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and
R.sup.9 are, for example, hydrogen or alkyl;
Ar.sub.2 is selected from the group consisting of aryl and heteroaryl;
p is an integer of from 0 to 6, inclusive; and,
q is an integer of from 0 to 14, inclusive.
Um composto ativo do receptor do cálcio da novela que tem a fórmula é fornecido: Ar.sub.1 -- [CR.sup.1 R.sup.2 ].sub.p -- X -- [CR.sup.3 R.sup.4 ].sub.q -- [CR.sup.5 R.sup.6 ] -- NR.sup.7 -- [CR.sup.8 R.sup.9 ] -- Ar.sub.2 wherein: Ar.sub.1 é selecionado do arilo, do heteroaryl, do bis(arylmethyl)amino, do bis(heteroarylmethyl)amino e do arylmethyl(heteroarylmethyl)amino consistindo do grupo; X são selecionados do oxigênio, do enxôfre, do sulfinyl, do sulfonyl, do carbonyl e do amino consistindo do grupo; R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8 e R.sup.9 são, para o exemplo, hidrogênio ou alkyl; Ar.sub.2 é selecionado do arilo e do heteroaryl consistindo do grupo; p é um inteiro de 0 a 6, inclusivo; e, q é um inteiro de 0 a 14, inclusivo.
