Compositions for the regulation of cytokine activity

   
   

A pharmaceutical composition for the regulation of cytokine activity in a subject. The composition features an effective amount of an oligosaccharide to inhibit the cytokine activity, preferably through inhibition of TNF-alpha activity. The oligosaccharide is more preferably up to four saccharide units in length, and optionally and more preferably, is N-sulfated with at least one other sulfur moeity. The compositions are useful for the treatment of various pathological conditions related to, caused by or promoted through, cytokine activity.

Uma composição pharmaceutical para o regulamento da atividade do cytokine em um assunto. A composição caracteriza uma quantidade eficaz de um oligosaccharide para inibir a atividade do cytokine, preferivelmente com a inibição da atividade do TNF-alfa. O oligosaccharide é mais preferivelmente até quatro unidades do saccharide no comprimento, e opcionalmente e mais preferivelmente, N-n-sulfated com ao menos outro um moeity do enxôfre. As composições são úteis para o tratamento das várias circunstâncias pathological relacionadas a, causadas perto ou promovidas completamente, atividade do cytokine.

 
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