GnRH receptor antagonists are disclosed which have utility in the treatment
of a variety of sex-hormone related conditions in both men and women. The
compounds of this invention have the structure:
##STR1##
wherein A, R.sub.1, R.sub.2, R.sub.3a, R.sub.3b, R.sub.4, R.sub.5, R.sub.6,
and n are as defined herein, including stereoisomers, prodrugs and
pharmaceutically acceptable salts thereof. Also disclosed are compositions
containing a compound of this invention in combination with a
pharmaceutically acceptable carrier, as well as methods relating to the
use thereof for antagonizing gonadotropin-releasing hormone in a subject
in need thereof.
