Compare core LPS (lacking O-polysaccharide side chains) from Gram-negative
bacteria are incorporated into a vaccine typically in liposomes. The
complete core of E. coli K 12 is particularly useful. Upon administration
to a mammal the vaccine stimulates synthesis of antibodies which are
cross-protective against smooth and rough forms of LPS from at least two
different Gram-negative bacterial strains having different core
structures.
