Topical administration of amifostine and related compounds

   
   

The present invention is directed to methods of treating or protecting mucosal tissue from damage associated with radiation and/or chemotherapeutic treatment of cancers, by the topical application of amifostine and related compounds. These methods avoid the side effects of systemically applied radio/chemo protectants. The invention is also directed to treatment and prevention of infections associated with mucositis by topical application of amifostine and related compounds.

La présente invention est dirigée vers des méthodes de traiter ou de protéger le tissu muqueux contre des dommages liés au rayonnement et/ou au traitement chimiothérapeutique des cancers, par l'application topique de l'amifostine et des composés reliés. Ces méthodes évitent les effets secondaires des protectants systémiquement appliqués de radio/chemo. L'invention est également dirigée vers le traitement et la prévention des infections liées au mucositis par application topique d'amifostine et de composés reliés.

 
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> Process for the preparation of 4-[1-hydroxy -4-[4-(hydroxydiphenylmethly)-1-piperidinyl]-butyl]-.alpha., .alpha.-dimethylbenzeneacetic acid

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