Novel CARD-5 polypeptides, proteins, and nucleic acid molecules are
disclosed. In addition to CARD-5 proteins, and the invention further
provides CARD-5 fusion proteins, antigenic peptides and anti-CARD-5
antibodies. The invention also provides CARD-5 nucleic acid molecules,
recombinant expression vectors containing a nucleic acid molecule of the
invention, host cells into which the expression vectors have been
introduced and non-human transgenic animals in which a CARD-5 gene has
been introduced or disrupted. Diagnostic, screening and therapeutic
methods utilizing compositions of the invention are also provided.