The invention provides methods of using dihydroxy unsaturated fatty acids
as markers for identifying patients with a disorder associated with
abnormal regulation of the cytochrome P450 metabolism or oxidation of
unsaturated fatty acids. For example, linoleic acid diols, including
leukotoxindiol, can be used as a diagnostic tool for identifying patients
with pre-eclampsia, eclampsia, and pregnancy-induced hypertension.