This invention is directed to mutant SPE-C toxins or fragments thereof,
vaccine and pharmaceutical compositions, and methods of using the vaccine
and pharmaceutical compositions. The preferred SPE-C toxin has at least
one amino acid change and is substantially non-lethal compared with the
wild type SPE-C toxin. The mutant SPE-C toxins can form vaccine
compositions useful to protect animals against the biological activities
of wild type SPE-C toxin.
