The present invention provides isolated polypeptides having VEGF antagonist
activity, pharmaceutical compositions and methods of treatment. The
polypeptides of the invention include polypeptides comprising a portion of
SEQ ID NO: 1 having VEGF antagonist activity, polypeptides comprising SEQ
ID NO: 2 or a portion thereof having VEGF antagonist activity, and a
polypeptide having the structure of formula (I), set forth above. The
present invention further includes analogs and derivatives of these
polypeptides having VEGF antagonist activity.
