G protein-coupled receptor up-regulated in prostate cancer and uses thereof

   
   

A novel gene (designated PHOR-1) that is highly over-expressed in prostate and other cancers and its encoded protein are described. PHOR-1 is a G protein-coupled receptor with homology to receptors involved in olfaction. PHOR-1 in normal human tissues is restricted to prostate, and this gene is highly over-expressed in prostate cancer as well as in cancers of the kidney, uterus, cervix, stomach and rectum. Consequently, PHOR-1 provides a diagnostic and/or therapeutic target for prostate cancer.

Un gene del romanzo (indicato PHOR-1) che altamente sopra-è espresso in prostata ed altri cancri e la relativa proteina messa è descritto. PHOR-1 è un ricevitore proteina-accoppiato G con l'omologia ai ricevitori addetti all'olfatto. PHOR-1 in tessuti umani normali si limita alla prostata e questo gene altamente sopra-è espresso nel cancro della prostata così come nei cancri del rene, dell'utero, della cervice, dello stomaco e del retto. Di conseguenza, PHOR-1 fornisce un obiettivo diagnostico e/o terapeutico per il cancro della prostata.

 
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