An antiretroviral composition for inhibiting the action of reverse
transcriptase include a nucleoside analog containing a six-carbon levo
hexose sugar, for example, L-rhamnose or L-fucose. Treatment is achieved
by delivering the antiretroviral to the infected system, wherein the
reverse transcription process is inhibited via steric hindrance, halting
the viral RNA replication. Delivery may be accomplished by conventional
methods, such as via oral dosing or injection. Additional delivery methods
are also contemplated, including packaging in liposomes and protein
targeting. The composition and method are also useful for inhibiting the
proliferation of cancer cells by halting the transcription process.
