Composition and method for inhibiting reverse transcript of a retrovirus

   
   

An antiretroviral composition for inhibiting the action of reverse transcriptase include a nucleoside analog containing a six-carbon levo hexose sugar, for example, L-rhamnose or L-fucose. Treatment is achieved by delivering the antiretroviral to the infected system, wherein the reverse transcription process is inhibited via steric hindrance, halting the viral RNA replication. Delivery may be accomplished by conventional methods, such as via oral dosing or injection. Additional delivery methods are also contemplated, including packaging in liposomes and protein targeting. The composition and method are also useful for inhibiting the proliferation of cancer cells by halting the transcription process.

 
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> Stable protein and nucleic acid formulations using non-aqueous, anhydrous, aprotic, hydrophobic, non-polar vehicles with low reactivity.

~ 00131