The invention relates to a multiparticulate modified release composition
that in operation delivers an active ingredient in a pulsed or bimodal
manner. The multiparticulate modified release composition comprises an
immediate release component and a modified release component; the
immediate release component comprising a first population of active
ingredient containing particles and the modified release component
comprising a second population of active ingredient containing particles
coated with a controlled release coating; wherein the combination of the
immediate release and modified release components in operation deliver the
active ingredient in a pulsed or a bimodal manner. The invention also
relates to a solid oral dosage form containing such a multiparticulate
modified release composition. The plasma profile achieved by the
multiparticulate modified release composition is advantageous in reducing
patient tolerance to the active ingredient and in increasing patient
compliance by reducing dosage frequency.
