Novel oligomers, and synthesis thereof, comprising one or more bi-, tri, or
polycyclic nucleoside analogues are disclosed herein. The nucleoside
analogues have a "locked" structure, termed Locked Nucleoside Analogues
(LNA). LNA's exhibit highly desirable and useful properties. LNA's are
capable of forming nucleobase specific duplexes and triplexes will single
and double stranded nucleic acids. These complexes exhibit higher
thermostability than the corresponding complexes formed with normal
nucleic acids. The properties of LNA's allow for a wide range of uses such
as diagnostic agents and therapeutic agents in a mammal suffering from or
susceptible to, various diseases.
