The present invention provides a process of preparation of naphthochlorins
and other chlorins with annelated ring systems useful for photodynamic
therapy and the compounds themselves. The method for producing
naphthochlorin compounds include contacting compounds such as
meso-(2'-hydroxymethyl)phenyl porphyrin or
meso-(2'-N,N,N-trialkylaminomethyl)phenyl porphyrin precursors with at
least one acid catalyst at sufficient temperature for a sufficient time to
yield the desired conversion. In a similar manner chlorins possessing
annelated ring systems may be made from compounds such as
meso-(2'-hydroxymethyl)aryl porphyrins or
meso-(2'-N,N,N-trialkylaminomethyl)phenyl porphyrin. The procedures
described herein provide new routes for synthesizing naphthochlorins and
chlorins with annelated ring systems.
La presente invenzione fornisce un processo della preparazione dei naphthochlorins ed altri chlorins con annelated i sistemi dell'anello utili per la terapia photodynamic ed i residui essi stessi. Il metodo per produrre i residui di naphthochlorin include mettersi in contatto con i residui quali la porfirina di meso-(2'-hydroxymethyl)phenyl o meso-(2'-N, la N, precursori della porfirina di N-trialkylaminomethyl)phenyl con almeno un catalizzatore acido alla temperatura sufficiente affinchè un tempo sufficiente renda la conversione voluta. In un modo simile i chlorins che possiedono annelated i sistemi dell'anello possono essere fatti dai residui quali le porfirine di meso-(2'-hydroxymethyl)aryl o meso-(2'-N, la N, porfirina di N-trialkylaminomethyl)phenyl. Le procedure descritte qui forniscono i nuovi itinerari per sintetizzare i naphthochlorins ed i chlorins con annelated i sistemi dell'anello.
