Methods and compositions for enhancing magnetic resonance imaging

   
   

Substantially nontoxic manganese complexes of compounds of the formula: ##STR1## wherein n=0, 1 or 2, R.sub.1 and R.sub.2 are hydrogen or alkyl groups of 1 to 4 carbon atoms, and R.sub.3 and R.sub.4 are hydrogen, alkyl groups of 1 to 4 carbon atoms or halogen, are useful for enhancing magnetic resonance images of body organs and tissues. Illustrative manganese complexes of such compounds include dihydrogen bis(N-[N'-(2,6-Diisopropylphenyl)-carbamoylmethyl-]iminodiaceto)manganese( II) monohydrate, dihydrogen bis[N-[N'-(2,6-dimethylphenyl)-carbamoylmethyl]iminodiaceto)-manganese(II) trihydrate, and dihydrogen bis(N-[N'-(2,6-dimethylpheny)carbamoylmethyl]iminodiaceto) manganese(II) dihydrate.

Complexes essentiellement non-toxiques de manganèse des composés de la formule : ## du ## STR1 où n=0, 1 ou 2, R.sub.1 et R.sub.2 sont hydrogène ou les groupes alcoyle de 1 à 4 atomes de carbone, et R.sub.3 et R.sub.4 sont hydrogène, les groupes alcoyle de 1 à 4 atomes de carbone ou l'halogène, soyez utile pour augmenter des images de résonance magnétique des organes et des tissus de corps. Les complexes d'illustration de manganèse de tels composés incluent le monohydrate du dihydrogène bis(N-[N'-(2,6-Diisopropylphenyl)-carbamoylmethyl-]iminodiaceto)manganese(II), le trihydrate du dihydrogène bis[N-[N'-(2,6-dimethylphenyl)-carbamoylmethyl]iminodiaceto)-manganese(II), et le dihydrate de manganese(II) du dihydrogène bis(N-[N'-(2,6-dimethylpheny)carbamoylmethyl]iminodiaceto).

 
Web www.patentalert.com

< Retracting MRI head coil

< Coolant cooled RF body coil

> Paramagnetic polymerized protein microspheres and methods of preparation thereof

> Planar radio frequency coil for open magnetic resonance imaging systems

~ 00135