The present invention provides the amino acid of a protein that inhibits
cellular apoptosis, herein termed the Survivin protein and nucleic acid
molecules that encode Survivin. Based on this disclosure, the present
invention provides isolated Survivin protein, isolated Survivin encoding
nucleic acid molecules, methods of isolating other members of the Survivin
family of proteins, methods for identifying agents that block Survivin
mediated inhibition of cellular apoptosis, methods of using agents that
block Survivin mediated inhibition or Survivin expression to modulate
biological and pathological processes, and methods of assaying Survivin
activity.
