The present invention relates to a gene delivery vehicle comprising a
recombinant adenovirus having a tropism for a primary human chondrocyte.
By efficiently transducing a nucleic acid of interest into a primary
chondrocytes, the gene delivery vehicle is able to at least in part
improve the counteraction of cartilage disease. In one embodiment the
recombinant adenovirus comprises a deletion in the gene encoding for fiber
protein, which is replaced by a nucleic acid sequence encoding at least
part of a fiber protein of a B-type adenovirus.
