To determine the transplant compatibility of an in vitro cultured tissue, a
method measures the stiffness of the cultured tissue by using a stiffness
measuring device, which stiffness measuring device includes a detecting
unit and calculation means, the detecting unit includes a contact unit, a
vibrator connected to the contact unit, and a vibration detecting unit for
detecting the vibration of the vibrator, and the calculation means
determines stiffness information by calculation based on the detected
result from the vibration detecting element; and by bringing the contact
unit into contact with the cultured tissue. With this method the
transplant compatibility of the cultured tissue can be nondestructively
and easily determined easily and the quality of the cultured tissue can be
appropriately controlled.