Certain novel 4-substituted N-acylated piperidine derivatives are agonists
of the human melanocortin receptor(s) and, in particular, are selective
agonists of the human melanocortin-4 receptor (MC-4R). They are therefore
useful for the treatment, control, or prevention of diseases and disorders
responsive to the activation of MC-4R, such as obesity, diabetes, sexual
dysfunction, including erectile dysfunction and female sexual dysfunction.
Determinados derivatives N-n-acylated do piperidine da novela 4-substituted são agonists do receptor(s) humano do melanocortin e, no detalhe, são agonists seletivos do receptor melanocortin-4 humano (MC-4R). São conseqüentemente úteis para o tratamento, o controle, ou a prevenção das doenças e dos disorders responsivos à ativação de MC-4R, tal como o obesity, diabetes, dysfunction sexual, including o dysfunction erectile e o dysfunction sexual fêmea.
