The invention provides full-length, human isolated nucleic acids molecules,
designated MEKK1 nucleic acid molecules, which encode a MEKK family
member. The invention also provides antisense nucleic acid molecules,
recombinant expression vectors containing MEKK1 nucleic acid molecules,
host cells into which the expression vectors have been introduced, and
nonhuman transgenic animals in which a MEKK1 gene has been introduced or
disrupted. The invention still further provides isolated MEKK1 proteins,
fusion proteins, antigenic peptides and anti-MEKK1 antibodies. Diagnostic
methods utilizing compositions of the invention are also provided.
