Dihydrobenzopyrans, dihydrobenzothiopyrans, and tetrahydroquinolines for the treatment of COX-2 mediated disorders

   
   

A class of dihydrobenzopyrans, dihydrobenzothiopyrans, tetrahydroquinolines, tetrahydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula (I) wherein X, A.sup.1, A.sup.2, A.sup.3, A.sup.4, R, R", R.sup.1 and R.sup.2 are as described in the specification ##STR1##

Una clase de dihydrobenzopyrans, de dihydrobenzothiopyrans, de tetrahydroquinolines, de tetrahydronaphthalenes, y de análogos de eso, se describe para el uso en desórdenes mediados cyclooxygenase-2 que tratan. Los compuestos del interés particular son definidos por Formula (i) en donde X, A.sup.1, A.sup.2, A.sup.3, A.sup.4, R, R ", R.sup.1 y R.sup.2 están según lo descrito en el ## del ## STR1 de la especificación

 
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