Process for the preparation of the cyclic pentapeptide
cyclo(Arg-Gly-Asp-DPhe-NMeVal)
by cyclization of a linear pentapeptide selected from the group consisting
of
H-Arg(Pbf)-Gly-Asp(OBzl)-DPhe-NMeVal-OH,
H-Gly-Asp(OBzl)-DPhe-NMeVal-Arg(Pbf)-OH,
H-Asp(OBzl)-DPhe-NMeVal-Arg(Pbf)-Gly-OH,
H-DPhe-NMeVal-Arg(Pbf)-Gly-Asp(OBzl)-OH or
H-NMeVal-Arg(Pbf)-Gly-Asp (OBzl)-DPhe-OH,
subsequent protective group removal and, if appropriate, further conversion
into its physiologically acceptable salts.
