Methods of diagnosing and treating Crohn's disease using Pseudomonas antigens

   
   

The present invention provides a method of identifying an agent useful in treating Crohn's disease. This method is practiced by culturing P. fluorescens under conditions that support growth; contacting the P. fluorescens with an agent; and assaying for reduced growth or viability of the P. fluorescens as compared to the growth or viability in the absence of the agent, where the reduced growth or viability of the P. fluorescens indicates that the agent is an anti-P. fluorescens agent useful in treating Crohn's disease. Also provided by the invention is a method of preventing or treating Crohn's disease in an individual by administering to the individual an effective dose of an anti-Pseudomonas vaccine.

A invenção atual fornece um método de identificar um agente útil na doença de Crohn de tratamento. Este método é praticado cultivando P. fluorescens sob as circunstâncias que suportam o crescimento; contatando o P. fluorescens com um agente; e assaying para o crescimento ou o viability dos fluorescens do P. em comparação ao crescimento ou o viability reduzido na ausência do agente, onde o crescimento ou o viability reduzido dos fluorescens do P. indicam que o agente é um agente dos fluorescens de anti-P. útil na doença de Crohn de tratamento. É fornecido também pela invenção um método de impedir ou de tratar a doença de Crohn em um indivíduo administrando ao indivíduo um dose eficaz do os anti-anti-Pseudomonas vacinais.

 
Web www.patentalert.com

< Cell-specific and/or tumor-specific promoter retargeting of herpes 34.5 gene expression

< Antibiotic inducible/repressible genetic construct for gene therapy or gene immunization

> DNA encoding apoptosis-induced eucaryotic initiation factor-5A and deoxyhypusine synthase and a method for controlling apoptosis in animals and humans

> Composition comprising multipotent neural stem cells for generation of hematopoietic cells

~ 00146