Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and TACE inhibitors

   
   

Compounds of the formula ##STR1## are useful in treating disease conditions mediated by TNF-.alpha., such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.

Los compuestos del ## del ## STR1 del fórmula son útiles en las condiciones de la enfermedad que tratan mediadas por TNF-.alpha., tal como artritis reumatoide, osteoartritis, sepsis, SIDA, colitis ulcerative, esclerosis múltiple, enfermedad de Crohn y pérdida degenerativa del cartílago.

 
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