The present invention provides a method for decreasing cerebral
vasoconstriction in a subject suffering from chronic or acute cerebral
amyloid angiopathy which comprises administering to the subject an
inhibitor of receptor for advanced glycation endproduct (RAGE) in an
effective amount to inhibit transcytosis of amyloid .beta. peptides across
the blood-brain barrier in the subject, thereby decreasing cerebral
vasoconstriction in the subject. The invention further provides for a
method for ameliorating neurovascular stress in a subject which comprises
administering to the subject an effective amount of an inhibitor of
receptor for advanced glycation endproduct (RAGE), so as to increase
cerebral blood flow in the subject, thereby ameliorating neurovascular
stress in the subject.
