Compositions and methods are provided for the treatment of conditions
associated with cell proliferation, cell differentiation and cell
survival. In particular, the dual-specificity phosphatase DSP-15, and
polypeptide variants thereof that stimulate dephosphorylation of DSP-15
substrates, are provided. The polypeptides may be used, for example, to
identify antibodies and other agents that inhibit DSP-15 activity. The
polypeptides and agents may be used to modulate cell proliferation,
differentiation and survival.
As composições e os métodos são fornecidos para o tratamento das circunstâncias associadas com o proliferation da pilha, o differentiation da pilha e a sobrevivência da pilha. No detalhe, o phosphatase DSP-15 do duplo-dual-specificity, e os variants do polypeptide disso que estimulam o dephosphorylation das carcaças DSP-15, são fornecidos. Os polypeptides podem ser usados, para o exemplo, identificar os antibodies e os outros agentes que inibem a atividade DSP-15. Os polypeptides e os agentes podem ser usados modular o proliferation, o differentiation e a sobrevivência da pilha.
