A new use of immunosuppressant for treating or preventing MMp-medicated
diseases is provided. The preferred immunosuppresants are tacrolimus,
cyclosporing A or 33-epi-chloro-33-desoxyascomycin (pimecrolimus).
Particularly, preferable MMP-mediated diseases are the diseases or
conditions caused by gelatinase and/or collagenase, and/or inflammatory
diseases concerned with gelatinase; such as arthritis (e.g.,
osteoarthritis, rheumatoid arthritis, etc.) cerebral diseases (e.g.,
stroke, etc.), tissue ulceration (e.g., corneal, epidermal and
gastriculceration, etc.), abnormal wound healing, periodontal diseases,
bone diseases (e.g., Paget's diseases, osteoporosis. etc.), tumor growth,
tumor metastasis or invasion, HIV-infection, decubitus, decubitis ulcer,
restenosis, epidermolysis bullosa, sepsis, septic shock, neoplasm,
psoriasis, neovascularization and multiple sclerosis.
Un nuovo uso del immunosoppressore per trattare o impedire le malattie MMp-medicate รจ fornito. I immunosuppresants preferiti sono tacrolimus, A o 33-epi-cloro-33-desoxyascomycin cyclosporing (pimecrolimus). Specialmente, le malattie MMP-mediate preferibili sono le malattie o le circostanze causate da gelatinasi e/o dalla collagenosi e/o malattie infiammatorie interessate di gelatinasi; quale l'artrite (per esempio, osteoartrite, artrite rheumatoid, ecc.) malattie cerebrali (per esempio, colpo, ecc.), ulcerazione del tessuto (per esempio, corneale, epidermico e gastriculceration, ecc.), ferita anormale che healing, malattie peridentali, malattie dell'osso (per esempio, malattie del Paget, osteoporosis. ecc.), sviluppo del tumore, metastasis o invasione del tumore, HIV-infezione, decubitus, ulcera di decubitis, restenosis, bullosa di epidermolysis, sepsis, scossa settica, neoplasma, psoriasis, neovascularization e sclerosi a placche.
