Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation

   
   

A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytokine cascade, for example endotoxic shock. The cholinergic agonist treatment can be effected by stimulation of an efferent vagus nerve fiber, or the entire vagus nerve.

Um método de inibir a liberação de um cytokine proinflammatory em uma pilha é divulgado. O método compreende o tratamento da pilha com um agonist cholinergic. O método é útil nos pacientes no risco para, ou em sofrer, de uma circunstância mediada por uma cascata inflammatory do cytokine, para choque endotóxico do exemplo. O tratamento cholinergic do agonist pode ser efetuado pelo stimulation de uma fibra efferent do nervo do vagus, ou pelo nervo inteiro do vagus.

 
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