Heterocytes as inhibitors of leucocyte adhesion and as VLA-4 antagonists

   
   

The present invention relates to compounds of the formula I ##STR1## which are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 which belongs to the group of integrins. The invention also relates to processes for the preparation of formula I, pharmaceutical compositions containing compounds of formula I, and the treatment or prophylaxis of various diseases caused by or are associated with excess leucocyte adhesion and/or leucocyte migration, as well as diseases associated with cell-cell or cell-matrix interactions, which on interactions of VLA-4 receptors with their ligands play a part of, for example, inflammatory processes, rheumatoid arthritis or allergic disorders.

A invenção atual relaciona-se aos compostos do ## do ## STR1 da fórmula I que são inibidores da adesão e da migração dos leucocytes e/ou antagonistas do receptor VLA-4 da adesão que pertence ao grupo dos integrins. A invenção relaciona-se aos processos para a preparação da fórmula I, as composições pharmaceutical que contêm compostos da fórmula I, e o tratamento ou a profilaxia das várias doenças causadas perto ou é associada também com a adesão do leucocyte e/ou a migração adicionais do leucocyte, as.well.as as doenças associadas com as interações da pilha-pilha ou da pilha-matriz, de que em interações dos receptors VLA-4 com seus ligands jogue uma parte, para o exemplo, processos inflammatory, arthritis rheumatoid ou disorders allergic.

 
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