Use of copolymer 1 and related peptides and polypeptides and T cells treated therewith for neuroprotective therapy

   
   

Methods are provided for treating injury to or disease of the central or peripheral nervous system. In one embodiment, treatment is effected by administering activated T cells that recognize an antigen of Cop 1 or a Cop 1-related peptide or polypeptide to promote nerve regeneration or to prevent or inhibit neuronal degeneration within the nervous system. In another embodiment, treatment involves administering Cop 1 or a Cop 1-related peptide or polypeptide to promote nerve regeneration or to prevent or inhibit neuronal degeneration in the nervous system, either the central nervous system or the peripheral nervous system. The activated T cells, which have been activated by the presence of Cop 1 or a Cop 1-related peptide or polypeptide, can be administered alone or in combination with Cop 1 or a Cop 1-related peptide or polypeptide.

Los métodos se proporcionan para lesión que trata a o la enfermedad del sistema nervioso central o periférico. En una encarnación, el tratamiento es efectuado administrando las células de T activadas que reconocen un antígeno del poli 1 o un peptide o un polipéptido del poli 1-related para promover la regeneración del nervio o para prevenir o para inhibir la degeneración neuronal dentro del sistema nervioso. En otra encarnación, el tratamiento implica el administrar del poli 1 o un peptide o un polipéptido del poli 1-related para promover la regeneración del nervio o para prevenir o para inhibir la degeneración neuronal en el sistema nervioso, el sistema nervioso central o el sistema nervioso periférico. Las células de T activadas, que han sido activadas por la presencia del poli 1 o un peptide o un polipéptido del poli 1-related, se pueden administrar solamente o conjuntamente con el poli 1 o un peptide o un polipéptido del poli 1-related.

 
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