Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate
HAM112 are claimed, as well as (a) antigen constructs comprising fusions
of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M
env polypeptide and (b) further antigen constructs containing additional
Group O sequences and especially the gp41 IDR of isolate HAM112. Also
claimed are polynucleotide sequences encoding the above, expression
vectors comprising the same, host cells transformed thereby, and
immunoassay methods and kits utilizing the antigen constructs of the
invention.
