The invention includes selected novel optically active .alpha.-amino
ketones which either are themselves useful or are intermediates for the
preparation of known ketomethylene pseudopeptides useful as antibiotics,
antibiotic enhancers, or enzyme inhibitors. Further, the present invention
provides a method for dehydrogenation/asymmetrical hydrogenation to obtain
essentially pure antipodes of ketomethylene pseudopeptides having two
chiral centers.
A invenção inclui cetonas ativas selecionadas da novela ótica as alpha.-amino que são elas mesmas úteis ou são os intermediários para a preparação dos pseudopeptides sabidos do ketomethylene úteis como antibióticos, enhancers antibióticos, ou inibidores de enzyme. Mais mais, a invenção atual fornece um método para o hydrogenation de dehydrogenation/asymmetrical para obter essencialmente antipodes puros dos pseudopeptides do ketomethylene que têm dois centros chiral.
