Methods and compositions for the treatment of gastrointestinal disorders

   
   

The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.

La invención del presente ofrece las composiciones y los métodos relacionados para tratar IBS y otros desórdenes y condiciones gastrointestinales (e.g., los desórdenes gastrointestinales del motility, los desórdenes gastrointestinales funcionales, la enfermedad gastroesophageal del reflujo (GERD), la enfermedad de Crohn, el colitis ulcerative, la enfermedad inflamatoria del intestino, el heartburn funcional, la dispepsia (dispepsia funcional incluyendo o dispepsia del nonulcer), el gastroparesis, la pseudo-obstruccio'n intestinal crónica (o la pseudo-obstruccio'n colonic), y los desórdenes y las condiciones se asociaron al estreñimiento, e.g., estreñimiento asociado al uso de los asesinos del dolor del nacrótico, estreñimiento post-surgical (íleo postoperatorio), y estreñimiento asociado a desórdenes neuropathic así como otras condiciones y a desórdenes usando los peptides y otros agentes que activan el cyclase C (el GCC del guanylate receptor.

 
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