2-pyrrolidone derivatives as prostanoid agonists

   
   

This invention relates to 8-aza prostanoid analogs which are generally EP.sub.4 receptor agonists and are represented by Formula I: ##STR1## wherein Q, B, X, J, Z, A and R.sup.1 -R.sup.6 are as defined, their synthesis and use for treatment of osteoporosis and increasing bone density.

Diese Erfindung bezieht auf Entsprechungen des Prostanoids 8-aza, die im Allgemeinen Empfänger EP.sub.4 Agonists sind und von Formula I dargestellt werden: ## STR1 ## worin Q, B, X, J, Z, A und R.sup.1 - R.sup.6 sind, wie definiert, ihre Synthese und Gebrauch für Behandlung der Osteoporose und der zunehmenden Knochendichte.

 
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