The present invention provides improved methods for conducting
living/controlled polymerization on polymeric solid supports. The improved
methods allow polymerization to occur directly from the non-functionalized
surface of a bulk support. In addition, polymerization may be re-initiated
to provide co-polymers. The disclosed methods may employ the
non-nitroxide-based RAFT and ATRP control agents that allow controlled
polymerization to proceed at relatively low temperatures (<80.degree.
C.). Furthermore, these improved methods may provide graft polymers with
decreased levels of "in-growth" of the bulk solid support. The invention
also provides substrate polymers, with improved properties for solid phase
synthesis and diagnostic applications, which may be made by the disclosed
methods.
La présente invention fournit des méthodes améliorées pour conduire la polymérisation de living/controlled sur les appuis pleins polymères. Les méthodes améliorées permettent à la polymérisation de se produire directement du non-functionalized la surface d'un appui en bloc. En outre, la polymérisation peut re-être lancée pour fournir des copolymères. Les méthodes révélées peuvent les agents utiliser de RADEAU et d'ATRP commande non-nitroxide-basée qui permettent à la polymérisation commandée de procéder aux températures relativement basses (
