The present invention concerns highly pure, crystalline, stable compounds
of novel derivatives of 3,3-diphenylpropylamines in the form of their
salts, a method for the manufacture and highly pure, stable intermediate
products.
The method is in particular characterized by regio- and chemoselectivity
and high yield. Salts of phenolic monoesters of 3,3-diphenylpropylamines
are provided, that are particularly well-suited for use in pharmaceutical
formulations. Preferred compounds are
R-(+)-2-(3-diisopropylamino-1-phenyl-propyl)-4-hydroxymethylphenylisobutyr
ate ester hydrogen fumarate and
R-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenylisobutyra
te ester hydrochloride hydrate. Furthermore, stable, crystalline
intermediate products that are essential for obtaining the abovementioned
salts are provided. A preferred intermediate product is
R-(-)-3-(3-diisopropylamino-phenyl-propyl)-4-hydroxy-benzoic acid methyl
ester.
La presente invenzione interessa i residui altamente puri, cristallini, stabili dei derivati del romanzo di 3,3-diphenylpropylamines sotto forma d'i loro sali, un metodo per la fabbricazione ed i prodotti intermedi altamente puri e stabili. Il metodo in particolare è caratterizzato da regio- e chemoselectivity ed alto rendimento. I sali dei monoesteri fenolici di 3,3-diphenylpropylamines sono forniti, quello sono particolarmente ben adattati per uso nelle formulazioni farmaceutiche. I residui preferiti sono R-(+)-2-(3-diisopropylamino-1-phenyl-propyl)-4-hydroxymethylphenylisobutyr hanno mangiato l'idrato del cloridrato dell'estere del fumarate dell'idrogeno dell'estere e del te di R-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenylisobutyra. Ancora, la scuderia, prodotti intermedi cristallini che sono essenziali per ottenere i sali suddetti è fornita. Un prodotto intermedio preferito è estere metilico acido di R-(-)-3-(3-diisopropylamino-phenyl-propyl)-4-hydroxy-benzoic.
