Methods and materials for preparing quinapril, its pharmaceutically
acceptable salts, including quinapril hydrochloride, are disclosed. The
method includes reacting
(2S,4S)-2-(4-methyl-2,5-dioxo-oxazolidin-3-yl)-4-phenyl-butyric acid ethyl
ester with (3S)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
tert-butyl ester to yield quinapril tert-butyl ester, which is
subsequently reacted with an acid to yield quinapril or an acid addition
salt of quinapril.
Os métodos e os materiais para preparar o quinapril, seus sais pharmaceutically aceitáveis, including o hydrochloride do quinapril, são divulgados. O método inclui reagir (2S, 4S)-2-(4-methyl-2, ester 5-dioxo-oxazolidin-3-yl)-4-phenyl-butyric ethyl ácido com (ester 3S)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic tert-tert-butyl ácido para render a quinapril o ester tert-tert-butyl, que é reagido subseqüentemente com um ácido ao quinapril do rendimento ou um sal da adição ácida do quinapril.
