Compositions and methods for the therapy and diagnosis of cancer,
particularly ovarian cancer, are disclosed. Illustrative compositions
comprise one or more ovarian tumor polypeptides, immunogenic portions
thereof, polynucleotides that encode such polypeptides, antigen presenting
cell that expresses such polypeptides, and T cells that are specific for
cells expressing such polypeptides. The disclosed compositions are useful,
for example, in the diagnosis, prevention and/or treatment of diseases,
particularly ovarian cancer.
As composições e os métodos para a terapia e o diagnóstico do cancer, particularmente cancer ovarian, são divulgados. As composições ilustrativas compreendem um ou mais polypeptides ovarian do tumor, parcelas immunogenic disso, os polynucleotides que codificam tais polypeptides, antígeno que apresentam a pilha que expressa tais polypeptides, e pilhas de T que são específicas para as pilhas que expressam tais polypeptides. As composições divulgadas são úteis, para o exemplo, no diagnóstico, na prevenção e/ou no tratamento das doenças, particularmente cancer ovarian.
