Kinases and uses thereof

   
   

Novel kinase polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length kinase proteins, the invention further provides isolated kinase fusion proteins, antigenic peptides, and anti-kinase antibodies. The invention also provides kinase nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

Os polypeptides do kinase da novela, as proteínas, e as moléculas do ácido nucleic são divulgados. Além às proteínas isoladas, full-length do kinase, a invenção fornece mais mais proteínas isoladas da fusão do kinase, peptides antigenic, e antibodies do anti-anti-kinase. A invenção fornece também moléculas do ácido nucleic do kinase, os vetores recombinant da expressão que contêm uma molécula do ácido nucleic da invenção, pilhas de anfitrião em que os vetores da expressão foi introduzido, e os animais transgenic nonhuman em que um gene do kinase foi introduzido ou disrupted. O diagnostic, a seleção, e os métodos therapeutic que utilizam composições da invenção são fornecidos também.

 
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