Treating neurological disorders using selective antagonists of persistent sodium current

   
   

The present invention provides methods of treating neurological disorders in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current.

A invenção atual fornece métodos de tratar disorders neurological em um mamífero administrando ao mamífero um uma quantidade eficaz de um antagonista persistente seletivo da canaleta do sodium que tenha ao menos o selectivity 20-fold para a corrente transiente relative.to do sodium da corrente persistente do sodium.

 
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