The ACP1 *A allele provides a means for diagnosing susceptability of a
human subject to hyperlipidemia, especially hyperlipidemia associated
with metabolic syndrome, a means for treating, or preventing the onset
of, hyperlipidemia and metabolic syndrome, and a means for screening and
identifying drugs suitable for use in treating or preventing
hyperlipidemia, especially hyperlipidemia associated with metabolic
syndrome. Diagnostic kits are also provided.